Dr Anne Savage

Lecturer

School School of Applied Sciences

Department Division of Health Sciences

Contact info

+44 (0)1382 30 8139

Biography

Qualifications

BSc (Hons) (1987) Dept of Pharmacolgy, University of Glasgow, Glasgow G12 8QQ
Ph.D. (1990) Dept of Biochemistry, Cambridge University, Cambridge CB2 1QW
PgD  (1995) Analytical Chemistry, Glasgow Caledonian University
Diploma in Computing Science (2000) Open University
PG.Cert (H.E) (2012) Abertay University and Dundee University
Diploma in Statistics (Due to complete June 2013) Open University

Previous posts

Daphne Jackson Fellowship (EPSRC funded). (Sept 2009-Sept 2011)

Centre for Research in Systems Pathology University of Abertay Dundee. Predicting length of stay in NHS acute wards from previous admission records. A modelling approach using data visualization.

Career break (1999 – 2009)  Freelance programming, data analysis and publishing contracts

Post-Doctoral Researcher (1995-1998) Caledonian Environment Centre, Glasgow Caledonian University.

Post-Doctoral Researcher (1992-1994) Dept of Biochemistry, University of Glasgow.

Wellcome Trust Travel Fellowship (1990-1991) Dept of Pharmacology and Endocrinology, CNRS-INSERM, Montpellier, France. 

Currently, I teach pharmacology on the following modules:

HS0907A; HS0917A; HS0916A; HS1006; HS0902

and statistics on these modules

FC0701A; BI0806A and FS0951A.

I also help out on BI0701A, BI0803A and BI0804A.

Interests

My research involves the use of image analysis techniques to relate morphological changes in breast cancer to disease classification and progress. This work is carried out in collaboration with Breakthrough Research Unit at the Western General Hospital,  Edinburgh. 

In cancer, morphological assessment of histological tissue samples is key to both diagnosis and prognosis. Traditional methods of analysing histological images introduce a degree of subjectivity to the assessment but image analysis techniques are able to support these

assessments through quantitative metrics of morphology. Generally, morphometric analysis is implemented on two-dimensional tissue sections data but this only represents a small fraction the tumour. Recent work carried out in collaboration with the Breakthrough research Unit, Edinburgh developed a  novel application of three-dimensional (3D) morphometrics for 3D imaging data obtained from tumours grown in a culture model. Minkowski functionals, a set of measures that characterise geometry and topology in ndimensional space were used to quantify tumour topology in the absence of and in response to therapeutic intervention(i.e. tamoxifen). The HER2 status of a tumour was found to predict the changes in morphological measures other than volume as a result of tamoxifen treatment ex vivo. In this study, we also demonstrated that Minkowski functionals may also be useful in predicting tumour grade.

http://dmm.biologists.org/content/early/2012/08/09/dmm.009886.abstract

Current work on 2-D images focuses on the morphology of breast cancer spheroids and the development of a range of measures derived from image analysis techniques that may be capable of discriminating between hormone receptor status and drug efficacy.

2019

Evaluation of Salmon (Salmo salar) and Rainbow Trout (Oncorhynchus mykiss) pin bones using textural analysis and micro X-ray computational tomography

Schroeder, S., Savage, A., Grigor, J. M., Sturrock, K. R., Cassidy, P., Topfl, S. & Wilkin, J. D. (2019) Evaluation of Salmon (Salmo salar) and Rainbow Trout (Oncorhynchus mykiss) pin bones using textural analysis and micro X-ray computational tomography. . . p. 3313-3319. .
View in Research Portal

2018

Evidence based survey of the distribution volume of ethanol

Maskell, P. D., Jones, A. W., Savage, A. & Scott-Ham, M. (2018) Evidence based survey of the distribution volume of ethanol. . . p. 124-131. .
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Identifying prognostic structural features in tissue sections of colon cancer patients using point pattern analysis

Jones-Todd, C. M., Caie, P., Illian, J. B., Stevenson, B. C., Savage, A., Harrison, D. J. & Bown, J. L. (2018) Identifying prognostic structural features in tissue sections of colon cancer patients using point pattern analysis. . . p. 1421-1441. .
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Evaluation of the one-step Lumicyano™ used in the visualisation of fingermarks on fabrics

Beerman, N., Savage, A., Dennany, L. & Fraser, J. (2018) Evaluation of the one-step Lumicyano™ used in the visualisation of fingermarks on fabrics. . . .
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2017

The effect of collagenase, water and calcium chloride on the removal of Salmo salar (salmon) and Oncorhynchus mykiss (trout) pin bones

Schroeder, S., Grigor, J. M., Stathopoulos, C. E., Savage, A., Cassidy, P., Toepfl, S. & Wilkin, J. D. (2017) The effect of collagenase, water and calcium chloride on the removal of Salmo salar (salmon) and Oncorhynchus mykiss (trout) pin bones. . . p. 1353-1363. .
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A comparison of penetration and damage caused by different types of arrowheads on loose and tight fit clothing

MacPhee, N., Savage, A., Noton, N., Beattie, E., Milne, L. & Fraser, J. (2017) A comparison of penetration and damage caused by different types of arrowheads on loose and tight fit clothing. . . p. 109-120. .
View in Research Portal

2015

Morphological analysis of cancer spheroids

Bown, J. L., Savage, A., Houston, A. N., Wilson, S., Khalil, H. S., Goltsov, A. & Deeni, Y. Y. (2015) Morphological analysis of cancer spheroids. . . p. S6. .
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2013

Progesterone significantly enhances the mobility of boar spermatozoa

Campbell, J. M., Savage, A. L., Madamidola, O., Tamhane, K., Soriano, R., Adya, A. K. & Brown, S. G. (2013) Progesterone significantly enhances the mobility of boar spermatozoa. . . .
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2012

Characterising the tumour morphological response to therapeutic intervention

Savage, A., Katz, E., Eberst, A., Falconer, R. E., Houston, A. N., Harrison, D. J. & Bown, J. L. (2012) Characterising the tumour morphological response to therapeutic intervention. . . p. 252-260. .
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2008

Decline in microbial activity does not necessarily indicate an end to biodegradation in MSW-biowaste

MacLeod, I., Savage, A., Pahl, O. & Baird, J. (2008) Decline in microbial activity does not necessarily indicate an end to biodegradation in MSW-biowaste. . . p. 8626-8630. .
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1998

A novel screening method for tetracycline in milk combining sensitized-Eu(III) fluorescence and immunoaffinity techniques

Savage, A. L., Sarijo, S. H. & Baird, J. (1998) A novel screening method for tetracycline in milk combining sensitized-Eu(III) fluorescence and immunoaffinity techniques. . . p. 1-4. .
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1995

A role for protein kinase C-mediated phosphorylation in eliciting glucagon desensitization in rat hepatocytes

Savage, A., Zeng, L. & Houslay, M. D. (1995) A role for protein kinase C-mediated phosphorylation in eliciting glucagon desensitization in rat hepatocytes. . . p. 281-285. .
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1994

Regulation of hepatocyte adenylate cyclase by amylin and CGRP

Houslay, M. D., Morris, N. J., Savage, A., Marker, A. & Bushfield, M. (1994) Regulation of hepatocyte adenylate cyclase by amylin and CGRP. . . p. 66-82. .
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1993

Involvement of protein kinase C in the first step of vasopressin sensitive phospholipase C homologous desensitization

Savage, A. L., Daro, F. & Gullion, G. (1993) Involvement of protein kinase C in the first step of vasopressin sensitive phospholipase C homologous desensitization. . . p. 121-138. .
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A mnemonical or negative-co-operativity model for the activation of adenylate cyclase by a common G-protein-coupled calcitonin-gene-related neuropeptide (CGRP)/amylin receptor

Bushfield, M., Savage, A., Morris, N. J. & Houslay, M. D. (1993) A mnemonical or negative-co-operativity model for the activation of adenylate cyclase by a common G-protein-coupled calcitonin-gene-related neuropeptide (CGRP)/amylin receptor. . . p. 229-236. .
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1992

Modulation of hormone-sensitive phospholipase C

Guillon, G., Mouillac, B. & Savage, A. L. (1992) Modulation of hormone-sensitive phospholipase C. . . p. 11-23. .
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1989

Vasopressin-stimulated Ca2+ influx in rat hepatocytes is inhibited in high-K+ medium

Savage, A. L., Biffen, M. & Martin, B. R. (1989) Vasopressin-stimulated Ca2+ influx in rat hepatocytes is inhibited in high-K+ medium. . . p. 821-827. .
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More Information

Funding

Melville Trust Vacation Scholarship in Cancer Research (2012)

Daphne Jackson Fellowship (2009-2011)

Outreach

Outreach

Women in Science Festival 2012 1st - 19th March: Introductory talk: 'Returning to a career in science after a career break'.

The Big Bang Scotland 12th June 2012: Project Judge

Meet the rest of the team

Mrs Suzanne Croy

Mrs Suzanne Croy

Division of Health Sciences | Lecturer

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Miss Fiona Stirling

Miss Fiona Stirling

Division of Health Sciences | Lecturer

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