My research interests are focused on reproductive physiology – in particular, the regulation of sperm function. In collaboration with Professor Chris Barratt at the University of Dundee and NHS Tayside, I’m investigating ion channel (dys)function in human sperm. From a research perspective, I’m also interested in pedagogic research in online teaching.
I completed my PhD in Neuroscience at University College London. Before joining Abertay University as a lecturer, I held postdoctoral research positions at University College London and the University of Dundee. My research experience includes investigating the electrophysiological and molecular analysis of GIRK channels, and the intracellular signalling pathways controlling ENaC expression.
I have previously acted as an external examiner for the Biotechnology degree at the Modern Science and Arts University in Cairo, Egypt.
Undergraduate module tutor responsibilities;
Dr. Brown has a pedagogic research interest in the area of online teaching/learning and assessment.
Dr. Brown is currently working in collaboration with Professor Chris Barratt at the University of Dundee and NHS Tayside working on the pathophysiology of human sperm. His background is as an electrophysiologist (patch clamp) and has an interest in the molecular control of ion channel function and is currently involved in a studying examining ion channel (dys)function in human sperm.
http://seanbrownblog.wordpress.com/ - contains selected research images
Kelly, M.C. Brown, S.G. Costello, S.M. Ramalingam, M. Drew, E. Publicover, S.J. Barratt, C.L.R. & Martins Da Silva, S. Single-cell analysis of [Ca2+]i signalling in sub-fertile men: characteristics and relation to fertilization outcome (2018). Human Reproduction. doi: 10.1093/humrep/dey096
Brown, S.G., Costello, S., Kelly, M.C., Ramalingam, M., Drew, E., Publicover, S.J., Barratt, C.L. & Martins da Silva, S.Complex CatSper-dependent and independent [Ca2+]i signalling in human spermatozoa induced by follicular fluid (2017). Human Reproduction. https://doi.org/10.1093/humrep/dex269
Martins da Silva, S.J., Brown, S.G., Sutton K., King, L.V., Ruso, H., Gray, D.W., Wyatt, P.G., Kelly, M.C., Barratt, C.L.R. & Hope A.G. Drug discovery for male subfertility using high-throughput screening: A new approach to an unsolved problem (2017). Human Reproduction. 32(5). 974-84.
Brown, S.G., Publicover, S.J., Mansell, S.A., Lishko, P.V., Williams, H.L., Ramalingam, M., Wilson, S.M., Barratt, C.L.R., Sutton, K.A. & Martins da Silva, S., Depolarization of sperm membrane potential is a common feature of men with subfertility and is associated with low fertilization rate at IVF (2016). Human Reproduction, 31(6), 1147-57.
Fernandes, G., Dasai, N., Kozlova, N., Mojadadi, A., Gall, M., Drew, E., Barratt, E., Madamidola, O.A., Brown, S.G., Milne, A.M., Martins da Silva, S.J., Whalley, K.M., Barratt, C.L. & Jovanovic, A. (2016). A spontaneous increase in intracellular Ca2+ in metaphase II human oocytes in vitro can be prevented by drugs targeting ATP-sensitive K channels. Human Reproduction, 31(2), 287-97.
Williams, H.L., Mansell, S., Alasmari, W., Brown, S.G. Wilson, S.M., Sutton, K. A., Miller, M.R., Lishko, P.V., Barratt, C.L., Publicover, S.J. & Martins da Silva, S. (2015). Specific loss of CatSper function is sufficient to compromise fertilizing capacity of human spermatozoa. Human Reproduction. 30(12), 2737-46.
Tardif, S., Madamidola, O.A., Brown, S.G., Frame, L., Lefievre, L., Wyatt, P.G., Barratt, C.L. & Martins Da Silva, S.J. (2014) Clinically relevant enhancement of human sperm motility using compounds with reported phosphodiesterase inhibitor activity. Human Reproduction 29(10), 2123-35.
Campbell, J., Savage, A.L., Madamidola, O., Tamhane, K., Soriano, R., Adya, A.K. & Brown, S.G. (2013). Progesterone significantly enhances the mobility of boar spermatozoa. Biodiscovery Journal, issue 9.
Gallacher, M., Brown, S.G., Hale, B.G., Fearns, R., Olver, R.E. & Wilson, S.M. (2009). Cation currents in human airway epithelial cells induced by infection with influenza A virus. J. Physiol., 587 (13), 3159-73.
Brown S.G. Gallacher, M., Olver, R.E. & Wilson, S.M. (2008). The regulation of selective and non selective Na+ conductances in H441 human airway epithelial cells. Am. J. Physiol., Lung Cell Mol. Physiol., 294(5), L942-54.
Martins da Silva, S.J., Mansell, S.A., Williams, H., Brown, S.G., Publicover, S.J., Wilson, S., & Barratt C.L.R (2014). Can a patch fix it? Electrophysiological studies of sperm and potential impact on clinical practice. European Society of Human Reproduction and Embryology meeting.
Campbell, J.M., Soriano, R. Tamhane, K., McCready P. & Brown, S.G. (2012). Progesterone increases the mobility of non capacitated boar sperm. Proc. Physiol. Soc, 26, PC
Naseem, Z., Gelli, S., Lester, D.H. & Brown, S.G. (2011). Cross species mapping of cAMP response element sites in promoter regions of genes involved in regulating sodium transport in the cortical collecting duct. Proc. Phyiol. Soc. 24, PC24.
Wildman, S.S. & Brown, S.G. (2010). The Complex Nature of P2 Receptor-Mediated Regulation of ENaC: Dependence on Na Concentration, Nucleotide Concentration and Exposure Time, and Tubular pH. American Society of Nephrology meeting presentation
Brown, S.G. (2012). Linking learning through provision of online learning content that is complementary to lecture material with the aid of online quizzes. E-assessment conference, University of Dundee.
Dr. Brown has been the recipient of Tenovus Scotland, Carnegie Scotland, Medical Research Council and Chief Scientist office grants.
External examiner for Biotechnology degree at Modern Science and Arts University, Cairo, Egypt (2012-14).
Reviewer for Human reproduction