Dr Sean Brown

Senior Lecturer

School School of Applied Sciences

Department Division of Health Sciences

Contact info

+44 (0)1382 30 8665

Biography

My research interests are focused on reproductive physiology – in particular, the regulation of sperm function. In collaboration with Professor Chris Barratt at the University of Dundee and NHS Tayside, I’m investigating ion channel (dys)function in human sperm. From a research perspective, I’m also interested in pedagogic research in online teaching.

I completed my PhD in Neuroscience at University College London.  Before joining Abertay University as a lecturer, I held postdoctoral research positions at University College London and the University of Dundee. My research experience includes investigating the electrophysiological and molecular analysis of GIRK channels, and the intracellular signalling pathways controlling ENaC expression.

I have previously acted as an external examiner for the Biotechnology degree at the Modern Science and Arts University in Cairo, Egypt.

Undergraduate module leader responsibilities;

  • LSC102 - Human Physiology
  • LSC204 - Medical Physiology
  • LSC303 - Transfusion Science
  • LSC404 - Advanced Pathophysiology

Dr. Brown has a pedagogic research interest in the area of online teaching/learning and assessment.

Interests

Dr. Brown is currently working in collaboration with Professor Chris Barratt at the University of Dundee and NHS Tayside working on the pathophysiology of human sperm.  His background is as an electrophysiologist (patch clamp) and has an interest in the molecular control of ion channel function and is currently involved in a studying examining ion channel (dys)function in human sperm.

2019

Novel pharmacological actions of Trequinsin Hydrochloride improve human sperm cell motility and function

McBrinn, R., Fraser, J., Hope, A., Gray, D., Barratt, C. L., Martins da Silva, S. J. & Brown, S. G. (2019) Novel pharmacological actions of Trequinsin Hydrochloride improve human sperm cell motility and function. . . .
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2018

The intracellular actions of trequinsin hydrochloride promotes human sperm motility

McBrinn, R., Brown, S. G., Fraser, J., Barratt, C. L. R., Martins da Silva, S., Gray, D. W. & Hope, A. G. (2018) The intracellular actions of trequinsin hydrochloride promotes human sperm motility. . . .
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2017

Single-cell analysis of [Ca2+]i signalling in sub-fertile men

Kelly, M. C., Brown, S. G., Costello, S. M., Ramalingam, M., Drew, E., Publicover, S. J., Barratt, C. L. & Martins da Silva, S. (2017) Single-cell analysis of [Ca2+]i signalling in sub-fertile men. . . p. 1023-1033. .
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Homozygous in-frame deletion in CATSPERE in a man producing spermatozoa with loss of CatSper function and compromised fertilizing capacity

Brown, S. G., Miller, M. R., Lishko, P. V., Lester, D. H., Publicover, S. J., Barratt, C. L. R. & Martins da Silva, S. (2017) Homozygous in-frame deletion in CATSPERE in a man producing spermatozoa with loss of CatSper function and compromised fertilizing capacity. . . p. 1812-1816. .
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2016

Complex CatSper-dependent and independent [Ca2+]i signalling in human spermatozoa induced by follicular fluid

Brown, S. G., Costello, S., Kelly, M. C., Ramalingam, M., Drew, E., Publicover, S. J., Barratt, C. L. & Martins da Silva, S. (2016) Complex CatSper-dependent and independent [Ca2+]i signalling in human spermatozoa induced by follicular fluid. . . p. 1995-2006. .
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Drug discovery for male subfertility using high-throughput screening

Martins da Silva, S. J., Brown, S. G., Sutton, K., King, L. V., Ruso, H., Gray, D. W., Wyatt, P. G., Kelly, M. C., Barratt, C. L. R. & Hope, A. G. (2016) Drug discovery for male subfertility using high-throughput screening. . . p. 974-984. .
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2015

Specific loss of CatSper function is sufficient to compromise fertilizing capacity of human spermatozoa

Williams, H. L., Mansell, S. A., Alasmari, W., Brown, S. G., Wilson, S. M., Sutton, K. A., Miller, M. R., Lishko, P. V., Barratt, C. L. R., Publicover, S. J. & Martins da Silva, S. J. (2015) Specific loss of CatSper function is sufficient to compromise fertilizing capacity of human spermatozoa. . . p. 2737-2746. .
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Depolarization of sperm membrane potential is a common feature of men with subfertility and is associated with low fertilization rate at IVF

Brown, S. G., Publicover, S. J., Mansell, S. A., Lishko, P. V., Williams, H. L., Ramalingam, M., Wilson, S. M., Barratt, C. L. R., Sutton, K. A. & Martins da Silva, S. J. (2015) Depolarization of sperm membrane potential is a common feature of men with subfertility and is associated with low fertilization rate at IVF. . . p. 1147-1157. .
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A spontaneous increase in intracellular Ca2+ in metaphase II human oocytes in vitro can be prevented by drugs targeting ATP-sensitive K+ channels

Fernandes, G., Dasai, N., Kozlova, N., Mojadadi, A., Gall, M., Drew, E., Barratt, E., Madamidola, O. A., Brown, S. G., Milne, A. M., Martins da Silva, S. J., Whalley, K. M., Barratt, C. L. R. & Jovanović, A. (2015) A spontaneous increase in intracellular Ca2+ in metaphase II human oocytes in vitro can be prevented by drugs targeting ATP-sensitive K+ channels. . . p. 287-297. .
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2014

Clinically relevant enhancement of human sperm motility using compounds with reported phosphodiesterase inhibitor activity

Tardif, S., Madamidola, O., Brown, S. G., Frame, L., Lefièvre, L., Wyatt, P. G., Barratt, C. L. R. & Martins da Silva, S. J. (2014) Clinically relevant enhancement of human sperm motility using compounds with reported phosphodiesterase inhibitor activity. . . p. 2123–2135. .
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2013

Progesterone significantly enhances the mobility of boar spermatozoa

Campbell, J. M., Savage, A. L., Madamidola, O., Tamhane, K., Soriano, R., Adya, A. K. & Brown, S. G. (2013) Progesterone significantly enhances the mobility of boar spermatozoa. . . .
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2009

Cation currents in human airway epithelial cells induced by infection with influenza A virus

Gallacher, M., Brown, S. G., Hale, B. G., Fearns, R., Olver, R. E., Randall, R. E. & Wilson, S. M. (2009) Cation currents in human airway epithelial cells induced by infection with influenza A virus. . . p. 3159-3173. .
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2007

A Ba2+-resistant, acid-sensitive K+ conductance in Na+-absorbing H441 human airway epithelial cells

Inglis, S. K., Brown, S. G., Constable, M. J., McTavish, N., Olver, R. E. & Wilson, S. M. (2007) A Ba2+-resistant, acid-sensitive K+ conductance in Na+-absorbing H441 human airway epithelial cells. . . p. 1304-1312. .
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2006

Expression of intermediate-conductance, Ca2+-activated K+ channel (KCNN4) in H441 human distal airway epithelial cells

Wilson, S. M., Brown, S. G., McTavish, N., McNeill, R. P., Husband, E. M., Inglis, S. K., Olver, R. E. & Clunes, M. T. (2006) Expression of intermediate-conductance, Ca2+-activated K+ channel (KCNN4) in H441 human distal airway epithelial cells. . . p. L957-L965. .
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Differential phosphoinositide binding to components of the G protein-gated K+ channel

Thomas, A. M., Brown, S. G., Leaney, J. L. & Tinker, A. (2006) Differential phosphoinositide binding to components of the G protein-gated K+ channel. . . p. 43-53. .
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2005

PKC-δ sensitizes Kir3.1/3.2 channels to changes in membrane phospholipid levels after M3 receptor activation in HEK-293 cells

Brown, S. G., Thomas, A., Dekker, L. V., Tinker, A. & Leaney, J. L. (2005) PKC-δ sensitizes Kir3.1/3.2 channels to changes in membrane phospholipid levels after M3 receptor activation in HEK-293 cells. . . p. C543-C556. .
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More Information

Funding

Dr. Brown has been the recipient of Tenovus Scotland, Carnegie Scotland, Medical Research Council and Chief Scientist office grants.

Esteem

Esteem

External examiner for Biotechnology degree at  Modern Science and Arts University, Cairo, Egypt (2012-14).

Reviewer for Human reproduction

Meet the rest of the team

Miss Lynne Thomas

Miss Lynne Thomas

Division of Health Sciences | Teaching Fellow

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Miss Marcia Stoll

Miss Marcia Stoll

Division of Health Sciences | Teaching Fellow

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