Dr Poornima Paramasivan

Postdoctoral Research Assistant

School School of Applied Sciences

Department Division of Health Sciences

Contact info

+44 (0)1382 30 8451

Biography

Professional Qualifications

PGcert in Higher Education Teaching, Abertay University, 2018

Ph.D., Biotechnology (Cancer Biology), Bharathiar University, India, 2013

M.Sc., Biochemistry, Avinashilingam University, India, 2008

B.Sc., Biochemistry, Bharathiar University, India, 2006

Employment History

Post-doctoral research assistant, Abertay University, UK; Jun’ 17-present

Post-doctoral fellow, Bangor University, UK; Aug’ 14-Jan’16

Honorary Researcher, University of Liverpool, UK; Mar’14-Jun’14

Lecturer in Biotechnology, Bharathiar University, India; Jul’13-Dec’13

Personal Statement

Following a Bachelor's and a Master’s degree in Biochemistry, I carried out by doctoral studies in Bharathiar University, India in collaboration with National Dong Hwa University, Taiwan, studying molecular mechanisms involved in combination therapy of neferine and doxorubicin to induce  autophagy and apoptosis in lung cancer cells. Then I have relocated to United Kingdom to pursue my postdoctoral fellowship in cancer. At the University of Liverpool, I studied the apoptosis mechanisms induced by maritoclax and Dinaciclib. Further in Bangor University, I have worked on the cellular uptake mechanism and anticancer efficiency of nitro-reductase coated gold magnetic nanoparticles for directed enzyme prodrug therapy (DEPT) in ovarian cancer cells. Currently, I am studying the role of NRF2 in ErbB targeted therapy in breast cancer cells.

LSC 202 - Cell biology and Immunology

2018

Biomaterial aided differentiation and maturation of induced pluripotent stem cells

Velmurugan, B. K., Priya, L. B., Paramasivan, P., Lee, L. & Baskaran, R. (2018) Biomaterial aided differentiation and maturation of induced pluripotent stem cells. . . p. 8443-8454. .
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Berbamine ameliorates isoproterenol-induced myocardial infarction by inhibiting mitochondrial dysfunction and apoptosis in rats

Saranya, S., Baskaran, R., Poornima, P. & Vijaya Padma, V. (2018) Berbamine ameliorates isoproterenol-induced myocardial infarction by inhibiting mitochondrial dysfunction and apoptosis in rats. . . p. 3101-3113. .
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2017

Neferine potentiates the antitumor effect of cisplatin in human lung adenocarcinoma cells via a mitochondria-mediated apoptosis pathway

Sivalingam, K. S., Paramasivan, P., Weng, C. F. & Viswanadha, V. p. (2017) Neferine potentiates the antitumor effect of cisplatin in human lung adenocarcinoma cells via a mitochondria-mediated apoptosis pathway. . . p. 2865-2876. .
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Biopiracy versus one-world medicine – from colonial relicts to global collaborative concepts

Efferth, T. ., Banerjee, . M. ., Abu-Darwish, M. S. ., Abdelfatah, S. ., Bockers, M. ., Bhakta-Guha, D., Bolzani, V., Daak, S., Demirezer, O. L. ., Dawood, . M., Efferth, . M. ., El-Seedi, . H. R. ., Fischer, . N., Greten, . H. J., Hamdoun, S. ., Hong, C. ., Horneber, . M. ., Kadioglu, . O. ., Khalid, . H. E. ., Khalid, S. A., Kuete, V. ., Mahmoud, N., Marin, J. ., Mbaveng, . A., Midiwo, J. ., Nakagawa, . H. ., Naß, . J., Ngassapa, O. ., Ochwang, D. ., Omosa, L. K. ., Ooko, . E. A. ., Özenver, . N. ., Paramasivan, P., Rodriguez Romero, . M. ., Saeed, M. E. ., Salgueiro, L. ., Seo, E. ., Yan, . G. ., Yasin, . Z. ., Saeed, . E. M. & Paul, . N. W. (2017) Biopiracy versus one-world medicine – from colonial relicts to global collaborative concepts. . . p. 319-331. .
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2016

Neferine prevents autophagy induced by hypoxia through activation of Akt/mTOR pathway and Nrf2 in muscle cells

Baskaran, R., Poornima, P., Priya, L. B., Huang, C. Y. & Padma, V. V. (2016) Neferine prevents autophagy induced by hypoxia through activation of Akt/mTOR pathway and Nrf2 in muscle cells. . . p. 1407-1413. .
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2015

Identification of novel nitroreductases from Bacillus cereus and their interaction with the CB1954 prodrug

Gwenin, V. V., Poornima, P., Halliwell, J., Ball, P., Robinson, G. & Gwenin, C. D. (2015) Identification of novel nitroreductases from Bacillus cereus and their interaction with the CB1954 prodrug. . . p. 392-402. .
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A comparative study on biologically and chemically synthesized silver nanoparticles induced Heat Shock Proteins on fresh water fish Oreochromis niloticus

Girilal, M., Krishnakumar, V., Poornima, P., Mohammed Fayaz, A. & Kalaichelvan, P. T. (2015) A comparative study on biologically and chemically synthesized silver nanoparticles induced Heat Shock Proteins on fresh water fish Oreochromis niloticus. . . p. 461-468. .
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Eicosapentaenoic acid prevents TCDD-induced oxidative stress and inflammatory response by modulating MAP kinases and redox-sensitive transcription factors

Palanisamy, K., Krishnaswamy, R., Paramasivan, P., Chih-Yang, H. & Vishwanadha, V. P. (2015) Eicosapentaenoic acid prevents TCDD-induced oxidative stress and inflammatory response by modulating MAP kinases and redox-sensitive transcription factors. . . p. 4726-4740. .
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Neferine prevents NF-κB translocation and protects muscle cells from oxidative stress and apoptosis induced by hypoxia

Baskaran, R., Poornima, P., Huang, C. Y. & Padma, V. V. (2015) Neferine prevents NF-κB translocation and protects muscle cells from oxidative stress and apoptosis induced by hypoxia. . . p. 407-417. .
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Network pharmacology of cancer

Paramasivan, P., Kumar, J. D., Zhao, Q., Blunder, M. & Efferth, T. . (2015) Network pharmacology of cancer. . . p. 290-302. .
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Maritoclax and dinaciclib inhibit MCL-1 activity and induce apoptosis in both a MCL-1-dependent and -independent manner

Varadarajan, S., Poornima, P., Milani, M., Gowda, K., Amin, S., Wang, H. G. & Cohen, G. M. (2015) Maritoclax and dinaciclib inhibit MCL-1 activity and induce apoptosis in both a MCL-1-dependent and -independent manner. . . p. 12668-12681. .
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2013

New organometallic ruthenium(ii) complexes containing chelidonic acid (4-oxo-4H-pyran-2,6-dicarboxylic acid)

Kamatchi, T. S., Kalaivani, P., Poornima, P., Padma, V. V., Fronczek, F. R. & Natarajan, K. (2013) New organometallic ruthenium(ii) complexes containing chelidonic acid (4-oxo-4H-pyran-2,6-dicarboxylic acid). . . p. 2004-2022. .
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Synthesis and structural characterization of new ruthenium(II) complexes and investigation of their antiproliferative and metastatic effect against human lung cancer (A549) cells

Kalaivani, P., Prabhakaran, R., Paramasivan, P., Huang, R., Hornebecq, V., Dallemer, F., Vijaya Padma, V. & Natarajan, K. (2013) Synthesis and structural characterization of new ruthenium(II) complexes and investigation of their antiproliferative and metastatic effect against human lung cancer (A549) cells. . . p. 20363-20378 . .
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Neferine, an alkaloid from lotus seed embryo, inhibits human lung cancer cell growth by MAPK activation and cell cycle arrest

Poornima, P., Weng, C. F. & Padma, V. V. (2013) Neferine, an alkaloid from lotus seed embryo, inhibits human lung cancer cell growth by MAPK activation and cell cycle arrest. . . p. 121-131. .
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Doxorubicin induced apoptosis was potentiated by neferine in human lung adenocarcima, A549 cells

Poornima, P., Kumar, V. B., Weng, C. F. & Padma, V. V. (2013) Doxorubicin induced apoptosis was potentiated by neferine in human lung adenocarcima, A549 cells. . . p. 87-98. .
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Neferine from Nelumbo nucifera induces autophagy through the inhibition of PI3K/Akt/mTOR pathway and ROS hyper generation in A549 cells

Poornima, P., Weng, C. F. & Padma, V. V. (2013) Neferine from Nelumbo nucifera induces autophagy through the inhibition of PI3K/Akt/mTOR pathway and ROS hyper generation in A549 cells. . . p. 3598-3605. .
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2012

Oral treatment with gallic acid and quercetin alleviates lindaneinduced cardiotoxicity in rats

Padma, V. V., Poornima, P., Prakash, C. & Bhavani, R. (2012) Oral treatment with gallic acid and quercetin alleviates lindaneinduced cardiotoxicity in rats. . . p. 134-140. .
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DNA binding, antioxidant, cytotoxicity (MTT, lactate dehydrogenase, NO), and cellular uptake studies of structurally different nickel(II) thiosemicarbazone complexes

Prabhakaran, R., Kalaivani, P., Huang, R., Paramasivan, P., Vijaya Padma, V. ., Dallemer, F. & Natarajan, K. (2012) DNA binding, antioxidant, cytotoxicity (MTT, lactate dehydrogenase, NO), and cellular uptake studies of structurally different nickel(II) thiosemicarbazone complexes. . . p. 223-247. .
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Neferine induces reactive oxygen species mediated intrinsic pathway of apoptosis in HepG2 cells

Poornima, P., Quency, R. S. & Padma, V. V. (2012) Neferine induces reactive oxygen species mediated intrinsic pathway of apoptosis in HepG2 cells. . . p. 659-667. .
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Protective effect of neferine against isoproterenol-induced cardiac toxicity

Lalitha, G., Poornima, P., Archanah, A. & Padma, V. V. (2012) Protective effect of neferine against isoproterenol-induced cardiac toxicity. . . p. 168-179. .
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More Information

Funding

Senior Research Fellowship, Council of Scientific and Industrial Research, India, April, 2012

Junior Research Fellowship,  Department of Science and Technology (DST), India and National Science Council (NSC), Taiwan, 2010 

Travel awards (3 Nos.), Department of Science and Technology (DST), India, 2010-2013.

Esteem

Esteem

Membership to Professional bodies

Member of British Association of Cancer Research

Member of European Association of Cancer Research

Member of Royal Society of Biology (MRSB), 2019

Fellow of Higher Education Academy (FHEA), 2018

Awards/Funding

Senior Research Fellow, Council of Scientific and Industrial Research, India, 2012

Junior Research Fellow, Department of Science and technology, India and National Science Council, Taiwan, 2010 

Award for academic excellence, Avinashilingam University, India, 2008

Award for academic excellence, Bharathiar University, India, 2006

Invited talks

Resource person: “Role of NRF2 in drug resistance and cancer therapy” in the international conference on Biozone 2018 -Current trends in cancer research and therapeutics, Sacred Heart College, Thiruvalluvar University, India; 2018

Resource person: “NRF2 in chemo-resistance” in the lecture series on cancer at Sree Ramakrishna College of Arts and Science for Women, Bharathiar University, India; 2018

Resource person: “Targeting the shadows of redox modulating NRF2 to combat drug resistance in cancer” in the Technical seminar on cancer at Sree Narayana Guru College of Arts and Science, Bharathiar University, India; 2018

Keynote speaker: “Neferine as a double-edged sword towards doxorubicin resistance and cardiotoxicity” in the International conference of translational medicine at Institute of Biotechnology, National Dong Hwa University, Taiwan;  2011

Outreach

Outreach

“A role for NRF-2 in the mechanism of action and effectiveness of dual tyrosine kinase inhibitor, lapatinib, in breast cancer cells” at 2018 NCRI Cancer Conference, taking place on at the Scottish Event Campus, Glasgow, UK; 2018

“Neferine as a chemosensitizing agent against doxorubicin resistant human lung adenocarcinoma cells” in World Biodiscovery Congress -2018, Dundee, UK; 2018

“Neferine, bisbenzyl-isoquinoline alkaloid from  lotus  (Nelumbo  nucifera  gaertn)  induces mitochondria mediated apoptosis in liver cancer cells”, at Mitochondria in Biology and Medicine  at Centre for cellular and molecular biology (CCMB), Hyderabad, India; 2011

“Optimizing cellular uptake of enzyme/gold coated magnetic nanoparticle conjugates for directed enzyme prodrug therapy (DEPT) for cancer” in LSRNW 1st annual drug discovery congress of Sêr Cymru – Life Sciences and Health NRN, Cardiff, UK; 2014

“Ginsenoside bioconversion by bacterial β-glucosidase” in MINDCRAFT at Karunya University, India;  2007

“Medicinal and nutritional importance of chicory”, at Nutraceuticals and the future of medical science” at Kongunadu Science College, India; 2007

Meet the rest of the team

Ms Julia McLeod

Ms Julia McLeod

Division of Health Sciences | Lecturer

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Dr Mhairi Thurston

Dr Mhairi Thurston

Division of Health Sciences | Senior Lecturer

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