Dr Alexey Goltsov

Lecturer

School School of Science, Engineering and Technology

Department Division of Science

Contact info

+44 (0)1382 30 8432

Biography

I’m a Computational Biologist with expertise in systems biology, bioinformatics, environment engineering, and data analysis. I’m currently a SISCA Lecturer in Computational Biology.

Previously, I held senior scientist position at the Biosystems Informatics Institute, Newcastle and postdoctoral research associate position at the Centre of Systems Biology of Edinburgh (CSBE), University of Edinburgh. Before coming to the UK, I held senior academic positions in Moscow including 15 years as an Associate Professor at the Department of biomedical technics and equipment, the Moscow Technological University (MIREA) and Head of the Computing Division at the State Institute of Physics and Technology, Moscow. 

Working closely with experimentalist and clinicians groups in the UK, US, and Russia I focus on the computational modelling, data analysis and the development of computational frameworks to support experimental interdisciplinary research in systems biology, bioinformatics, pharmacology, physical chemistry, clinical trials, and environmental engineering.  Now I am working on computational systems biology of cancer signalling therapy and medical engineering in cancer laser therapy.  I am also involved in the systems physiology project on the non-invasive diagnostics of cerebrovascular diseases. I have worked on the GlaxoSmithKline project on the bacterial strain improvement for pharmacological biotechnology.  In the field of environment engineering (soil decontamination and utilization of e-waste) I have four PCT patents.

I hold an MSc and PhD in Physics from Moscow State University. In 2004 I had a title of an Associate Professor in Cybernetics from the Russian Ministry of Education, Moscow. In 2017 I got the degree of Doctor of Science in Biophysics and Bioengineering as a result of defensing dissertation “Computational system biology methods in personalised oncotherapy” in the Faculty of Physics, Moscow State University, Russia.

I’m the Chief Editor of the Journal of Bioanalysis and Biomedicine. I am also a Review Editor for Systems Biology and Guest Associate Editor for Vascular Physiology in Frontiers in Physiology journal. Since 2009 I have co-authored 20 publications in peer-reviewed journals:
https://www.scopus.com/authid/detail.uri?origin=resultslist&authorId=56234051200&zone=

Professional Qualifications:

2017                 Doctor of Science, Dissertation “Computational system biology methods in personalised oncotherapy”, 

                         Faculty of Physics, Moscow State University, Russia

2004                Title of Associate Professor in the field of Cybernetics given by the Ministry of Education, Russia

1988                PhD, Faculty of Physics, Moscow State University, Russia

1984                MSc, Faculty of Physics, Moscow State University, Russia

Professional Employment History:

2012-to date  SICSA Reader  (The Scottish Informatics and Computer Science Alliance), School of Science Engineering & Technology, Abertay Uniiversity.

2010-2012    SICSA Lecturer, School of Contemporary Sciences, Abertay University.

2008-2010    Post-Doctoral Research Associate, Centre for Systems Biology of Edinburgh, University of  Edinburgh, Edinburgh, UK

2006-2008    Senior Researcher, Biosystems Informatics Institute, Newcastle-upon-Tyne, UK

1992-2006    Associate Professor, Department of Cybernetics, Moscow University of informatics, Radiotechnology, and Electronics (MIREA), Moscow, Russia.

2000-2002    Associate Professor, Department of Applied mathematics, Moscow Technical University, Moscow, Russia.

1987-2002   Head of Division of Computing, State Institute of Physics & Technology, Moscow, Russia

 

Teaching

2016/2017

EEM100 Engineering Science 1;
EEM102 Engineering Science 2 (Module Leader);
EEM298 Structures and Mathematics;
FOR305 Forensic Material Investigation;
ELE016 The Art and Science of Decision Making. 

2015/2016

BN0825A - Mathematics for Civil Engineering (Module Tutor)

BN0710A - Mathematics and the Mechanics of Materials 

AN0611A - Access to Science & Technology

HS0801A - Human Physiology 2 

FS0906A - Forensic Material Investigation

BI0806A -Techniques and Skills 2 

 

Internal Reviewer of degree programmes:

2015: BSc (Hons) Sport and Exercise Science Programme including the following modules: SP0701A, SP0701A, SP0702A, SP0703A, SP0704A, SP0705A, SP0801A, SP0802A, SP0803A, SP0804A, SP0805A,  SP0806A, SP0901A, SP0902A, SP0903A, : SP0904A, SP0905A, SP0906A, SP0907A, SP0908A, SP0909A, SP0910A, SP0911A, SP0912A, SP1001A, SP1002A, SP1003A, SP1004A, SP1005A, SP1006A, SP1007A, SP1008A, SP1010A, SP1011A, and SP1013A.

Suppervision of Master and PhD students:

1. Supervisor of 5 Master students (MbR) projects in Bioinformatics in SSET.
2. Supervisor of current PhD student in Systems Biology of Cancer, in SSET (start in January 2015).
 

Membership in Committees:

Member of the program committee of SICSA PhD Conference 2015, Glasgow

 

Recent Alumni:

Stylianos Kyriakidis. Bioinformatic Analysis of Global Gene Expression: Dynamics of the NRF2-KEAP1 Signaling System in Ovarian Cancer and its Treatment. 2013 (MbR project under joint supervision with Dr. Yusuf  Deeni)

Joint publications on the results of this work:
1. Goltsov A, Deeni Y, Khalil HS, Soininen T, Kyriakidis S, Hu H, Langdon SP, Harrison DJ, Bown J. Systems Analysis of Drug-Induced Receptor Tyrosine Kinase Reprogramming Following Targeted Mono- and Combination Anti-Cancer Therapy. Cells 2014, 3(2), 563-591; doi:10.3390/cells3020563.
2. Goltsov A, Deeni Y, Khalil H, Idowu M, Kyriakidis S, Goltsov G, Langdon SP, Harrison DJ,  Bown J. Role of Post-translational Regulation of PTEN Activity in Cancer Cell Addiction to Heterozygous PTEN Mutations. In book PTEN: Structure, Mechanisms-of-Action, Role in Cell Signaling and Regulation. Editors: Ke Xu. Nova Science Publishers, 2013 (pp. 173-210)


Tero Soininen. Bioinformatics analysis of the NRF2 antioxidant pathway in response to targeted therapy in cancer. 2013 (MbR project under joint supervision with Dr. Yusuf  Deeni)

Joint publication on the results of this work:
1. Goltsov A, Deeni Y, Khalil HS, Soininen T, Kyriakidis S, Hu H, Langdon SP, Harrison DJ, Bown J. Systems Analysis of Drug-Induced Receptor Tyrosine Kinase Reprogramming Following Targeted Mono- and Combination Anti-Cancer Therapy. Cells 2014, 3(2), 563-591; doi:10.3390/cells3020563.

2. Khalil HS, Langdon SP, Goltsov A, Soininen T, Harrison DJ, Bown J, Deeni YY. A novel mechanism of action of HER2 targeted immunotherapy is explained by inhibition of NRF2 function in ovarian cancer cells. Oncotarget. 2016 Oct 4. doi: 10.18632/oncotarget.

Student’s projects

I offer both a BSc and a more in-depth one-year MSc, PhD projects in biomedicine.

During research work on the different projects, students get experience in the computational methods of systems biology, bioinformatics, biostatistics, systems physiology, medical physics, computing in medicine and data science in biomedicine.

In their research students design and carry out computational (in silico) experiments using computational systems biology frameworks to analyse drug effects on the different cellular signalling and metabolic networks relating to diseases. In silico experiments are proposed in combination with in vitro and in vivo experiments carried out in different experimental groups in Abertay, St Andrews, Edinburgh, and Aston Universities which I closely collaborate with. During project implementation students are involved in the research carried out in SIMBIOS and CRISP and participate in writing joint manuscripts in the following areas:


Student’s projects:

1. Computational systems biology in cancer research. Computational modelling of the effects of anticancer drugs targeting signalling networks in cancer cells. Applications to in vitro and in vivo experimental data on anticancer drug efficacy depending on oncogenic mutation in cancerous cells.
2. Bioinformatics in cancer research. Computational analysis of microarray data on gene expression following to anticancer drug therapy.
3. Computational pharmacology: pharmacokinetics and pharmacodynamics (PK/PD) study of non-steroidal anti-inflammatory drugs (NSAIDs) effects on cyclooxygenase-1,2 (COX-1,2) relevant to inflammation and cancer. 
4. Computational systems physiology and medical physics. Computational modelling of haemodynamics and microvasculature regulation in health and disease.  Application to physiological monitoring of microvascular system by photonics methods.
5. Systems biotechnology.  Applications of systems biotechnology to strain improvement and anti-purine drug development.
 

My field of expertise is applied physics, environment engineering, computational data analysis, bioinformatics, and systems biology. I focus on the development of computational frameworks to support and inform interdisciplinary research in biophysics and environmental engineering.  Methods of computational modelling of complex natural processes and systems based on the analysis and incorporation of multimodal experimental data were successfully applied in the following research and industrial environment projects:

Environmental engineering: Research and Development of the technology of novel building concrete materials based on electronic waste utilization in civil and industrial engineering. Manager and PI of the EU ecological project  and author of four  PCT patents in building engineering.

Medical engineering in biophotonic diagnostics methods:   Development of a computational framework to support non-invasive biophotonic diagnostics of cerebrovascular diseases. Mathematical modelling of cerebrovascular microhaemodynamics based on Laser Doppler flowmetry (LDP) and its application to analysis of LDP clinical data on vasomotion response in patients with ischemic stroke.                Joint project of Abertay University and Optoelectronics and Biomedical Photonics Group, Aston Institute of Photonic Technologies, Aston University, Birmingham, UK.

Medical engineering in cancer laser therapy:  Mathematical modelling of the process underlying cancer laser therapy to control and optimize laser generation of reactive oxygen species by quantum-dot NIR laser diodes in cancer cells.
Joint project of Abertay University and Optoelectronics and Biomedical Photonics Group, Aston Institute of Photonic Technologies, Aston University, UK.

Pharmacology:  Computational modelling of cellular signalling networks and its application to experimental and clinical study of anticancer drug efficacy in personalised therapy. Development of mathematical methods to support design and test of the combination therapy targeting complex and rewiring signalling network in cancer cells. Joint project of Abertay, Edinburgh and St Andrews Universities.

Biotechnology:  Mathematical modelling of bacterial metabolism to support metabolic engineering and strain productivity improvement in pharmacological biotechnology. Joint project of Systems Biology group, Faculty of Bioengineering and Bioinformatics, Moscow State University and GlaxoSmithKline, UK.

Refereed publications (2017-2009)

  1. Goltsov A., Anisimova A.V., Zakharkina M., Krupatkin A.I., Sidorov V.V., Sokolovski S.G., Rafailov E.U. Bifurcation in blood oscillatory rhythms for patients with ischemic stroke: a small scale clinical trial using laser Doppler flowmetry and computational modelling of vasomotion. Frontiers in Physiology, 2017, 8:160. doi: 10.3389/fphys.2017.00160
  2. Bown JL, Shovman M, Robertson P, Boiko A, Goltsov A, Mullen P, Harrison DJ. A signaling visualization toolkit to support rational design of combination therapies and biomarker discovery: SiViT. Oncotarget. 2017; 8:29657-29667. doi: 10.18632/oncotarget.8747
  3. Semyachkina-Glushkovskaya O.V., Sokolovski S.G., Goltsov A., Gekaluyk A.S., Saranceva E.I., Bragina O.A.,  Tuchin V.V., Rafailov E.U. Laser-induced generation of singlet oxygen and its role in the cerebrovascular physiology. Progress in Quantum Electronics, 2017,  55 112–128.
  4. Goltsov A, Tashkandi G, Langdon SP, Harrison DJ, Bown JL. Kinetic modelling of in vitro data of PI3K, mTOR1, PTEN enzymes and on-target inhibitors Rapamycin, BEZ235, and LY294002. European Journal of Pharmaceutical Sciences,  97 (2017) 170–181.
  5. Khalil HS, Langdon SP, Goltsov A, Soininen T, Harrison DJ, Bown J, Deeni YY. A novel mechanism of action of HER2 targeted immunotherapy is explained by inhibition of NRF2 function in ovarian cancer cells. Oncotarget. 2016 Oct 4. doi: 10.18632/oncotarget.
  6.  Rao V. L. Papineni*, Shahid Umar, James Bown  and Alexey Goltsov*.Stress visualisation in gastrointestinal tract at different pathologies forwards a systems approach to drug repurposing. Journal of Bioanalysis & Biomedicine, Editorial, 2015, 7:e129. doi:10.4172/1948-593X.1000e129.
  7. Goltsov A, Sokolovski  SG, and Rafailov EU. Coupled ROS and Ca2+ Sustained Activation in Cancer Cells Induced by Near-Infrared Laser Pulse: Application for Cancer Therapy. Enliven: Bioinformatics. 1,  2/1, 2015.
  8. Tashkandi, G., Goltsov, A., Mullen, P., Bown, J., Harrison, D., & Langdon, S. (2015). Abstract B33: Understanding resistance mechanisms to PI3K/mTOR inhibitors in ovarian cancer model systems. Molecular Cancer Therapeutics, 14(7 Supplement), B33–B33. doi:10.1158/1538-8514.PI3K14-B33
  9. Khalil HS*, Goltsov A*, Langdon SP, Harrison DJ, Bown J, Deeni Y. Quantitative analysis of NRF2 pathway reveals key elements of the regulatory circuits underlying antioxidant response and proliferation of ovarian cancer cells. J Biotechnology, 11, 2014; DOI: 10.1016/j.jbiotec.2014.09.027, * the first authors.
  10. Goltsov A, Langdon SP, Harrison DJ,  Bown J. Dynamic Reprogramming of Signalling Networks – A New Challenge in Cancer Therapy. Enliven: Bioinformatics 09/2014; 1(1):e002. Editorial.
  11. Goltsov A, Deeni Y, Khalil HS, Soininen T, Kyriakidis S, Hu H, Langdon SP, Harrison DJ, Bown J.  Systems Analysis of Drug-Induced Receptor Tyrosine Kinase Reprogramming Following Targeted Mono- and Combination Anti-Cancer Therapy. Cells 2014, 3(2), 563-591; doi:10.3390/cells3020563.
  12. Goltsov, A, Langdon SP, Goltsov G, Harrison DJ, Bown J. Customizing the therapeutic response of signalling networks to promote antitumor responses by drug combinations. Frontiers in Oncology. 2014, 4, 13.
  13. Sokolovski S, Zolotovskaya S, Goltsov A, Pourreyron C, South A, Rafailov E.  Infrared laser pulse triggers increased singlet oxygen production in tumour cells. Scientific Reports, 2013, 3:3484.
  14. Adams R, Clark A, Yamaguchi A, Hanlon N, Tsorman N, Ali S, Lebedeva G, Goltsov A, Sorokin A, Akman OE, Troein C, Millar AJ, Goryanin I, Gilmore S. SBSI: An extensible distributed software infrastructure for parameter estimation in systems biology. Bioinformatics. 2013 Mar 1;29(5):664-5.
  15. Sokolovski SG, Goltsov A, Rafailov EU. Modelling the hypersensitivity of cancer cells to infra-red laser pulse: breaking ROS defence machinery. Conf. Paper. SPIE Photonics West 2013, BiOS 2013, Proc. SPIE 8568, Optical Methods for Tumor Treatment and Detection: 85680E; San Francisco, California, USA, February 02, 2013 doi:10.1117/12.2001715. (Conference paper)
  16. Goltsov A, Faratian D, Langdon SP, Harrison DJ, Bown J. Features of the reversible sensitivity-resistance transition in ERK/PI3K/PTEN/AKT signalling network at HER2 inhibition. Cellular Signalling. 2012 Feb;24(2):493-504.
  17. Lebedeva G, Sorokin A, Faratian D, Mullen P, Goltsov A, Langdon SP, Harrison DJ, Goryanin I. Model-based global sensitivity analysis as applied to identification of anti-cancer drug targets and biomarkers of drug resistance in the ErbB2/3 network. Eur J Pharm Sci. 2012, Jul 16;46(4):244-58.
  18. Bown J, Andrews PS, Deeni Y, Goltsov A, Idowu M,  Polack FAC, Sampson AT, Shovman M, Stepney S. Engineering simulations for cancer systems biology. Current Drug Targets, 2012 Nov;13(12):1560-74.
  19. Hu H*, Goltsov A*, Bown J, Sims AH, Langdon SP, Harrison DJ, Faratian D. Feedforward and feedback regulation of the MAPK and PI3K oscillatory circuit in breast cancer. Cellular Signalling. 2013 Jan;25(1):26-32. (* the first authors)
  20. Tummala H, Goltsov A, Khalil HS, Sproul A, Scott F, Mitev V, Zhelev N.  Advocating the need of prediction models for individualized prognosis and treatment in B-CLL disease patients. BioDiscovery.  2012, Dec 6: 3. 
  21. Idowu MA, Goltsov A, Khalil HS, Tummala H, Zhelev N, Bown Cancer research and personalised medicine: a new approach to modelling time-series data using analytical methods and Half systems.  Current Opinion in Biotechnology, Volume 22, Supplement 1, September 2011, Pages S59.
  22. Goltsov A, Goltsov G, Sampson A. Simulating the Effects of Anticoagulant Drugs Upon Blood Clotting Dynamics. In In Proceedings of the 2012 Workshop on Complex Systems Modelling and Simulation, CoSMoS 2012, 105-107.
  23. Goltsov A, Faratian D, Langdon SP, Bown J, Goryanin I, Harrison DJ. Compensatory effects in the PI3K/PTEN/AKT signaling network following receptor tyrosine kinase inhibition. Cellular Signalling. 2011, 23, 407-416.
  24. Goltsov A., Lebedeva G., Humphery-Smith I., Goltsov G., Demin O., Goryanin I. In Silico Screening of Nonsteroidal Anti-Inflammatory Drugs and Their Combined Action on Prostaglandin H Synthase-1.  Pharmaceuticals 2010, 3, 2059-2081.
  25. Faratian D*, Goltsov A*, Lebedeva G., Moodie S., Mullen P., Kay C., Um I. H., Langdon S., Goryanin I., and Harrison D. J. Systems biology reveals new strategies for personalising cancer medicine and confirms PTENs role in resistance to trastuzumab, Cancer Research 2009, 69, 6713. (* the first authors)
  26. Goltsov A., Maryashkin A., Swat M., Kosinsky Y., Humphery-Smith I., Demin O., Goryanin I., Lebedeva G. Kinetic modelling of NSAID action on COX-1: Focus on in vitro/in vivo aspects and drug combinations. European Journal of Pharmaceutical Sciences, 36, 2009, 122-136.
  27. Goltsov AN, Barsukov LI. Synergetics of the Membrane Self-Assembly: A Micelle-to-Vesicle Transition. Journal of Biological Physics, 2000; 26(1):27-41.

 

Dissertation

Goltsov A. “Computational system biology methods in personalised oncotherapy”. Habilitation thesis (DSc). Physical Faculty, the Moscow State University. 2017

  

Book chapters: 

  1. Bown J, Deeni Y, Goltsov A, Khalil H, Isaacs J, Li Y, Sampson AT, Savage A. and Zhelev N. Cancer systems biology: Integtating experimental and theoretical systems at cellular and tissue scales. In book Current Application of Biotechnology. Ed. M. Dundar, 357-386, Erciyes University Publishing, 2015, ISBN: 978-605-85579-0-1.
  2. Goltsov, A, Langdon SP, Goltsov G, Harrison DJ, Bown J. Customizing the therapeutic response of signaling networks to promote antitumor responses by drug combinations. In e-book Drug-Diagnostics Co-Development in Oncology. Ed. JT Jørgensen. Frontiers in Oncology. 85-98. 2014, ISBN 978-2-88919-332-5
  3. Goltsov A, Deeni Y, Khalil H, Idowu M, Kyriakidis S, Goltsov G, Langdon SP, Harrison DJ,  Bown J. Role of Post-translational Regulation of PTEN Activity in Cancer Cell Addiction to Heterozygous PTEN Mutations. In book: PTEN: Structure, Mechanisms-of-Action, Role in Cell Signaling and Regulation. Editors: Ke Xu. Nova Science Publishers, 2013, pp. 173-210.

PCT patents in civil and industrial engineering:

  1. Goltsov AN, Engovatov IA, Zaitseva EI, Lavdansky PA, Rumyantsev BM, Fisun OI: Building mortar. October 9, 2003:  PCT/RU2002/000138, WO/2003/082768.
  2. Goltsov AN, Engovatov IA, Zaitseva EI, Lavdansky PA, Rumyantsev BM, Fisun OI.: Raw mixture for producing cellular concrete. October 9, 2003: PCT/RU2002/000139, WO/2003/082768
  3. Goltsov AN, Engovatov IA, Zaitseva EI, Lavdansky PA, Rumyantsev BM, Fisun OI.: Concrete radiation protection mixture. October 9, 2003:  PCT/RU2002/000140, WO/2003/083878
  4. Goltsov AN, Engovatov IA, Zaitseva EI, Lavdansky PA, Rumyantsev BM, Fisun OI.: Binding agent for radiation protection building materials. October 2, 2003: PCT/RU2002/000111, WO/2003/080531

Conference talks and papers (2011-2015)

  1.  Alexey Goltsov,  Yusuf Deeni , Ghassan Tashkandi, Simon P. Langdon, David J. Harrison, James L. Bown. Computational Systems Pharmacology of biomarker design for signalling cancer therapy. Int. Conf. Circulating Biomarkers 2016. Abertay University, Dundee, 12-13 October. 2016.
  2. Alexey Goltsov, Ghassan Tashkandi, Simon P. Langdon, David J. Harrison, James L. Bown. Signalling therapy for cancer: from target proteins to target signalling networks. The  Controlling Cancer Summit 2016. O2 Arena. London 17-19 May. 2016.
  3. A. Goltsov, S.G. Sokolovski, E.U. Rafailov. Coupled  ROS and Ca2+ sustainable  activation in cancer cells induced by near-infrared laser pulse. In Proc. Scotland Roadshow Exhibition & Conference. Advances in photonic tools and techniques for the life sciences, 3rd June 2015 · Technology & Innovation Centre University of Strathclyde, Glasgow.
  4. Alexey Goltsov, Hilal S. Khalil, Simon P. Langdon, David J. Harrison, James Bown , Yusuf  Deeni. Systems biology study of the NRF2-KEAP regulatory mechanism of high level ROS homeostasis in ovarian cancer cells. In Proc.  Conf. The Keap1/Nrf2 Pathway in Health and Disease, 6—8 January 2015, Robinson College, Cambridge, UK.
  5. A.N. Goltsov, A.V. Anisimova, A.V. Zakharkina, A.I. Krupatkin,V.V. Sidorov, S.G. Sokolovski, E.U. Rafailov Computational modelling of cerebrovascular haemodynamics for non-invasive laser diagnostics of neuronal diseases. Proc. of SPIE Photonics Europe, 14-17 April 2014, Brussel.
  6. Alexey Goltsov, Simon P Langdon, David J Harrison, James Bown. Customising the therapeutic response of signalling networks through drug combinations to overcome/prevent anticancer drug resistance. Conf. Signalling and Acquired Resistance to Targeted Cancer Therapeutics. Bioochemical Society. 5-7 January 2014, Cambridge, UK. 
  7. A. Goltsov, A.V. Anisimova A.V. Zakharkina, A.I. Krupatkin,V.V. Sidorov, S.G. Sokolovski, E.U. Rafailov. Laser diagnostics of cerebral microheamodyanamics: bifurcation point in blood oscillatory rhythms for patients with ischemic stroke. Proc. of Scotland Roadshow Exhibition & Conference. Advances in photonic tools and techniques for the life sciences. Edinburgh Conference Centre, Heriot-Watt University, Edinburgh,  2014
  8. Sergei G. Sokolovski, Alexey Goltsov, Edik U. Rafailov, "Modelling the hypersensitivity of cancer cells to infra-red laser pulse: breaking ROS defence machinery", in Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII, David H. Kessel; Tayyaba Hasan, Editors, Proceedings of SPIE Vol. 8568 (SPIE, Bellingham, WA 2013), 85680E.
  9. Sokolovski SG, Zolotovskaya SA, Goltsov A, South AP, Pourreyron C, Rafailov EU, “Cancer cells start to generate ROS once been triggered by 1268 nm laser irradiation: modeling of cell apoptosis through well-known oxidative stress mechanisms”, SPIE Photonics Europe, Brussels, 8427-74, 2012.
  10. Invited talk: Analysis of Drug Sensitivity-Resistance Transition in the PI3K/PTEN/AKT Signalling Network to HER2 inhibition. 4th World Cancer Congress 2011, Dalian, China.
  11. Talk: A systems study of the control mechanisms underlying ERK and AKT signalling oscillation in cancer cells. The Scotish Stem Cell Network (SSCN) Biology Group Meeting, Apex Hotel, Dundee, Feb 23rd, 2012.
  12. Talk: Systems Biology of drug sensitivity-resistance transition in ErbB signaling in cancer. Biology + Computing=? A joint SICSA meeting of the CSE:SEABIS group and the ModAbs groupy. University of Stirling, May, 2012.
  13. Talk: “Computational modelling in Molecular Systems Medicine”. SICSA workshop Systems Medicine, University of Abertay Dundee, 11th May 2011.
  14.  Cancer cells start to generate singlet oxygen once been triggered by 1268-nm laser irradiation: modeling oxidative stress mechanism, by in Proceedings of SPIE Conference “Biophotonics: Photonic Solutions for Better Health Care", Vol. 8427, 16 - 19 April 2012, Brussels, Belgium.
  15.  A. Sampson, A. Goltsov, D. Faratian, S. Langdon, D. Harrison and J. Bown Upscaling cellular signalling models to the tissue-scale: a concurrent systems approach by Signalling 2011: A Biochemical Society Centenary Celebration, University of Edinburgh, June 2011.

More Information

Funding

My Lecturer and Reader positions are funded by Scottish Informatics and Computer Science Alliance (SICSA).

2012-2016 Northwood trust, £200K/year. Co-investigator. 

Esteem

  • A member of the program committee of SICSA PhD Conference 2015, Glasgow
  • 2015-to date Editor of Research Topic  in Frontiers in Physiology, section Vascular Physiology
  • 2009-to date   Chief Editor: Journal of Bioanalysis & Biomedicine,
  • 2009-to date Journal of Biological Informatics & Biodiversity, Bioinformatics (Enliven)
  • 2012-to date   Review Editor, Guest Associate Editor: Frontiers in Physiology, section Frontiers of Systems Biology
  • 2010-to date   Reviewer: PLOS ONE; Springer;  Frontiers in Physiology (Systems Biology); Frontiers in Genetics; Journal of Cancer Science & Therapy;  Drug Design, Development and Therapy; BioDiscovery; Journal of Molecular Pharmaceutics & Organic Process Research; OncoTargets and Therapy (Dovepress); Neuroscience Journal;  Research Reports in Clinical Cardiology; Disease Markers; Chinese Journal of Cancer Research; Molecules (MDPI), Processes (MDPI)
  • Reviewer:  MRC grant proposals

Knowledge Exchange

Collaboration and joint grant applications in the following field of research and development:

1. Research area: Environmental bioengineering and biotechnology:

The project: Microbial fuel cells - an emerging biotechnology in an economically and environmentally sustainable treatment of organic waste waters: Toward practical application – scale-up  & performance

Collaboration:
• Okinawa Institute Science and Technology, Biological Systems Unit (leading organization)
• Edinburgh University;
• Joint Centre Systems and Synthetic Biology, Tianjin University
• Abertay University
Foundation: The Industrial Biotechnology Innovation Centre (IBioIC), Glasgow
Submission time: 2015/2016

2. Research area: Biomedicine, Environment, Sociology.

The project: Implications of the Bystander Effect for Biomedical and Environmental Research

Collaboration:
• University of Stirling (leading organization)
• University of Edinburgh
• Queen's University Belfast
• University of Pavia
• McMaster University, CA
• University of Kansas
• Abertay University

Foundation: The Human Frontier Science Program (HFSP)
Submission: 2015/16

Joint publications and conference presentations:
1. Rao V. L. Papineni (1,2,3), Shahid Umar (1), James Bown and Alexey Goltsov. Stress visualisation in gastrointestinal tract at different pathologies forwards a systems approach to drug repurposing. Journal of Bioanalysis & Biomedicine, Editorial, 2015. in press.

(1) University of Kansas Medical Center, USA, (2)Precision X-Ray Inc North Branford, USA, (3)PACT & Health, Branford, USA, 

2. Ishfaq Ahmed (1); Shauna McLaughlin (2); Alexey Goltsov (3); Shahid Umar (1); Rao V. Papineni (4)
Radiation related gastrointestinal injuries differ during different stress conditions in mouse. Presentation at The 61st Annual Meeting of the Radiation Research Society Weston, FL, September 19-22, 2015
(1)University of Kansas KUMC, Kansas; (2) Precision X-ray Inc, Branford; (3)University of Abertay, Dundee, United Kingdom; and (4) University of Kansas KUMC, PXI and PACT & Health, Branford, CT

3. Research area: Non-invasive biophotonic technology and equipment

The project: Development of a non-invasive photonic platform for diagnosis of patients with cerebrovascular disease.

Collaboration:

  • Aston University, UK (leading organization)
  • Bispebjerg Hospital, Denmark,
  • University of Valencia,
  • University of Cologne,
  • 2M Engineering Ltd., NL,
  • SPE “LAZMA” Ltd., RU
  • Elfi-Tech Ltd., IL,
  • Oulu University, FI,
  • Abertay University

Foundation: 2015; 2016-2017 Horizon 2020 Health calls
Submission: 2014, 2015/16

Joint publications:

  1. Sokolovski S, Zolotovskaya S, Goltsov A, Pourreyron C, South A, Rafailov E.  Infrared laser pulse triggers increased singlet oxygen production in tumour cells. Scientific Reports, 2013, 3:3484.
  2. Sokolovski SG, Goltsov A, Rafailov EU. Modelling the hypersensitivity of cancer cells to infra-red laser pulse: breaking ROS defence machinery. Conf. Paper. SPIE Photonics West 2013, BiOS 2013, Proc. SPIE 8568, Optical Methods for Tumor Treatment and Detection: 85680E; San Francisco, California, USA, February 02, 2013 doi:10.1117/12.2001715. (Conference paper)

Joint authorship of Research topic issue in Frontiers in Physiology journal:
Advanced non-invasive photonic methods for functional monitoring of haemodynamics and vasomotor regulation in health and diseases.
A. Goltsov (1), V.V. Sidorov (2), S.G. Sokolovski (3), E.U. Rafailov (3)

(1) School of Science, Engineering and Technology, Abertay University, Dundee, UK;

(2) SPE “LAZMA” Ltd., Moscow, Russia;

(3) Optoelectronics and Biomedical Photonics Group, Aston Institute of Photonic Technologies, Aston University, Birmingham, UK.


Joint conference presentations
1. A.N. Goltsov, A.V. Anisimova, A.V. Zakharkina, A.I. Krupatkin,V.V. Sidorov, S.G. Sokolovski, E.U. Rafailov Computational modelling of cerebrovascular haemodynamics for non-invasive laser diagnostics of neuronal diseases. Proc. of SPIE Photonics Europe, 2014
2. A. Goltsov, A.V. Anisimova A.V. Zakharkina, A.I. Krupatkin,V.V. Sidorov, S.G. Sokolovski, E.U. Rafailov. Laser diagnostics of cerebral microheamodyanamics: bifurcation point in blood oscillatory rhythms for patients with ischemic stroke. Proc. of Advances in photonic tools and techniques for the life sciences. Edinburgh Conference Centre, Heriot-Watt University, 2014
3. Sergei G. Sokolovski, Alexey Goltsov, Edik U. Rafailov, "Modelling the hypersensitivity of cancer cells to infra-red laser pulse: breaking ROS defence machinery", in Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII, David H. Kessel; Tayyaba Hasan, Editors, Proceedings of SPIE Vol. 8568 (SPIE, Bellingham, WA 2013), 85680E.
4. Sokolovski SG, Zolotovskaya SA, Goltsov A, South AP, Pourreyron C, Rafailov EU, “Cancer cells start to generate ROS once been triggered by 1268 nm laser irradiation: modeling of cell apoptosis through well-known oxidative stress mechanisms”, SPIE Photonics Europe, Brussels, 8427-74, 2012.
 

4. Research area: Systems Medicine.

The project: Mitigation of gastrointestinal  radiation injury through the psycho-neuroendocrine- immune axis modulation: systems biology approach to drug repurposing and nutritional and pharmacologic pre/probiotic strategy development.

Collaboration:

  • University of Kansas Medical Center, KUMC, USA;
  • Precision X-Ray Inc North Branford, USA;
  • PACT & Health, Branford, USA;
  • Abertay University

Foundation: The Small Business Innovation Research (SBIR) program (USA)
Submission: autumn 2015

Joint publications and conference presentations:
1. Rao V. L. Papineni, Shahid Umar, James Bown and Alexey Goltsov. Stress visualisation in gastrointestinal tract at different pathologies forwards a systems approach to drug repurposing. Journal of Bioanalysis & Biomedicine, Editorial, 2015. in press.

2. Ishfaq Ahmed; Shauna McLaughlin; Alexey Goltsov; Shahid Uma; Rao V. Papineni. Radiation related gastrointestinal injuries differ during different stress conditions in mouse. Presentation at The 61st Annual Meeting of the Radiation Research Society Weston, FL, September 19-22, 2015

 

5. Research area: Amino acid production biotechnology

The project: E.coli strain improvement in amino acid production biotechnology: systems and synthetic biology approach. 

Collaboration:
• Joint Centre Systems and Synthetic Biology, China
• Abertay University

Foundation:Joint Centre Systems and Synthetic Biology, China

Project duration: 2015/2016

6. Research area: Systems Pharmacology 

The project: A Systems Biology Approach to investigation and modelling of the pathways linking the DNA Damage Response, Cell Cycle Checkpoint Control and Apoptosis: Application to the enhancement of chemotherapy.

Collaboration:

  • Abertay University (leading organization)
  • University of Edinburgh

Joint Publications:

Tummala H, Goltsov A, Khalil HS, Sproul A, Scott F, Mitev V, Zhelev N.  Advocating the need of prediction models for individualized prognosis and treatment in B-CLL disease patients. BioDiscovery.  2012, Dec 6: 3.

Bown J, Deeni Y, Goltsov A, Khalil H, Isaacs J, Li Y, Sampson AT, Savage A. and Zhelev N. Cancer systems biology: Integtating experimental and theoretical systems at cellular and tissue scales. In book Current Application of Biotechnology. Ed. M. Dundar, 357-386, Erciyes University Publishing, 2015, ISBN: 978-605-85579-0-1.
 

Foundation: EPSRC

Submission: September, 2015


 

Meet the rest of the team

Dr Douglas Lester

Dr Douglas Lester

Division of Science | Lecturer

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Dr Yusuf Deeni

Dr Yusuf Deeni

Division of Science | Senior Lecturer

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